Melatonin

Melatonin
Melatonin
	;
Općenito
Hemijski spoj	Melatonin
Druga imena	Circadin, Slenyto ; IUPAC ime: N-[2-(5-Metoksi-1H-indol-3-il)etil]acetamid
Molekularna formula	C13H16N2O2
InChI	1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
Osobine1
Molarna masa	232,278 g/mol
Tačka topljenja	117
	1 Gdje god je moguće korištene su SI jedinice. Ako nije drugačije naznačeno, dati podaci vrijede pri standardnim uslovima.

Melatonin, također poznat i kao N-acetil-5-methoksitriptamin je hormon kojeg prvenstveno luči epifiza, a regulira ciklus spavanja-budnosti.^[2] Kao dodatak prehrani, često se koristi za kratkotrajno liječenje nesanice, a uobičajeno se uzima oralno.^[3]^[4] Dokazi o njegovoj koristi za ovu upotrebu, međutim, nisu jaki.^[5] Pregledom iz 2017. utvrđeno je da je početak spavanja nastupio šest minuta brže uz upotrebu, ali nije našao promjenu ukupnog vremena spavanja.^[4] Lijek melatoninski receptor ramelteon može djelovati isto kao i dodaci melatoninu.^[4]

Melatonin je normalno pronađen kod većine životinja, uključujući i ljude, i nekih drugih živih organizama, kao što su alge. Razine u cirkulaciji variraju tokom dnevnog ciklusa, a melatononin je važan za regulaciju cirkadijskih ritmova nekoloiko bioloških funkcija. Mnogi biološki efekti melatonina idu preko aktivacije melatoninskih receptora, dok je za druge odgovorna njegova uloga prodirućeg i moćnog antioksidansa sa posebnom ulogom u zaštiti mitohondrijske i jedarne DNK.

^ "Melatonin - Drugs.com". Drugs.com. Pristupljeno 12. 10. 2018.
^ Faraone, Stephen V. (2014). ADHD: Non-Pharmacologic Interventions, An Issue of Child and Adolescent Psychiatric Clinics of North America, E-Book. Elsevier Health Sciences. str. 888. ISBN 9780323326025.
^ Buscemi N, Vandermeer B, Pandya R, Hooton N, Tjosvold L, Hartling L, et al. (novembar 2004). "Melatonin for treatment of sleep disorders" (PDF). Evidence Report/Technology Assessment No. 108. (Prepared by the University of Alberta Evidence-based Practice Center, under Contract No. 290-02-0023.) AHRQ Publication No. 05-E002-2. Rockville, MD: Agency for Healthcare Research and Quality. Agency for Healthcare Research and Quality (AHRQ), US Department of Health and Human Services (108): 1–7. doi:10.1037/e439412005-001. PMC 4781368. PMID 15635761. Arhivirano s originala (PDF), 3. 5. 2013. Pristupljeno 5. 6. 2013.
^ ^a ^b ^c Matheson E, Hainer BL (juli 2017). "Insomnia: Pharmacologic Therapy". American Family Physician. 96 (1): 29–35. PMID 28671376.
^ Brasure M, MacDonald R, Fuchs E, Olson CM, Carlyle M, Diem S, et al. (2015). "Management of Insomnia Disorder[Internet]". AHRQ Comparative Effectiveness Reviews. 15 (16): EHC027–EF. PMID 26844312.

[1] "Melatonin - Drugs.com". Drugs.com. Pristupljeno 12. 10. 2018.

[2] Faraone, Stephen V. (2014). ADHD: Non-Pharmacologic Interventions, An Issue of Child and Adolescent Psychiatric Clinics of North America, E-Book. Elsevier Health Sciences. str. 888. ISBN 9780323326025.

[Buscemi_2004-3] Buscemi N, Vandermeer B, Pandya R, Hooton N, Tjosvold L, Hartling L, et al. (novembar 2004). "Melatonin for treatment of sleep disorders" (PDF). Evidence Report/Technology Assessment No. 108. (Prepared by the University of Alberta Evidence-based Practice Center, under Contract No. 290-02-0023.) AHRQ Publication No. 05-E002-2. Rockville, MD: Agency for Healthcare Research and Quality. Agency for Healthcare Research and Quality (AHRQ), US Department of Health and Human Services (108): 1–7. doi:10.1037/e439412005-001. PMC 4781368. PMID 15635761. Arhivirano s originala (PDF), 3. 5. 2013. Pristupljeno 5. 6. 2013.

[AFP2017-4] Matheson E, Hainer BL (juli 2017). "Insomnia: Pharmacologic Therapy". American Family Physician. 96 (1): 29–35. PMID 28671376.

[Bra2015-5] Brasure M, MacDonald R, Fuchs E, Olson CM, Carlyle M, Diem S, et al. (2015). "Management of Insomnia Disorder[Internet]". AHRQ Comparative Effectiveness Reviews. 15 (16): EHC027–EF. PMID 26844312.

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